Lipoprotein Lipase Binds to Low Density Lipoprotein Receptors and Induces Receptor-mediated Catabolism of Very Low Density Lipoproteins
نویسندگان
چکیده
منابع مشابه
Catabolism of low density lipoproteins by perfused rabbit livers: Cholestyramine promotes receptor-dependent hepatic catabolism of low density lipoproteins (hepatic low density lipoprotein receptor/low density lipoprotein metabolism/hypercholesterolemia/casein diet/high density lipoprotein
Rabbits fed a wheat starch/casein diet develop a marked hypercholesterolemia accompanied by a decrease in the number of EDTA-sensitive binding sites on plasma membrane fractions of the liver for low density lipoproteins (LDL) and 13migrating very low density lipoproteins [Chao, Y.-S., Yamin, T.T. & Alberts, A. W. (1982)J. BioL Chem., in press]. Inclusion of 1% cholestyramine resin in this diet ...
متن کاملLow Density Lipoproteins Produced in Vitro by Lipoprotein Lipase Action on Nonsuppressive Very Low Density Lipoprdteins*
Very low density lipoproteins (VLDL), Sf60 to 400, from normolipemic individuals do not suppress 3-hydroxy-3-methylglutaryl-CoA reductase activity in cultured normal human fibroblasts at concentrations 20fold higher than those of low density lipoproteins (LDL) that give total suppression. To determine if these VLDL contain all of the structural elements necessary for receptor-mediated suppressi...
متن کاملReceptor-independent Catabolism of Low Density Lipoprotein
In this study we examine the effects of intravenous ethyl oleate emulsions on the metabolism of native and cyclohexanedione-modified human low density lipoprotein in rabbits. Treatment produced a highly significant faU in receptor-independent catabolism as measured by the fractional clearance rate of cyclohexanedione-modified low density lipoprotein. Receptor-dependent Catabolism (the differenc...
متن کاملReceptor-mediated low density lipoprotein catabolism in man.
Binding of human low density lipoproteins (LDL) to their specific receptor on cultured cells can be inhibited by treatment with 1,2-cyclohexanedione which blocks a number of functionally significant arginyl residues on the apolipoprotein. We have used this observation to examine the role of the receptor pathway in LDL catabolism in man. The plasma clearance rates of 125I-LDL and 131I-cyclohexan...
متن کاملLipoprotein Lipase Increases Low Density Lipoprotein Retention
Lipoprotein lipase (LPL), the rate-limiting enzyme for hydrolysis of plasma lipoprotein triglycerides, is a normal constituent of the arterial wall. We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). When bovine milk LPL was added to endothelial cell monolayers before addition of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.29.17073